Instead of using a tube with a tiny camera to detect cancer inside the body, engineers at the University of Buffalo have developed a bio-medical advancement not only to detect cancer but also zap cancerous tumours.
The new device, under development at the University at Buffalo, could make chemotherapy more efficient, reduce its side effects and improve how doctors treat some of the most deadly forms of cancer.
“We are developing a novel endoscopic device that will improve our ability to detect and destroy cancer cells,” says Ulas Sunar, researcher in UB’s Department of Biomedical Engineering.
Conventional endoscopic imaging has limitations in terms of its image contrast that is distorted due to scattered light absorbed by the body. This leads to blurred or low-contrast images of the tumor environment that limit doctors’ ability to visualize tumours.
To overcome these deficiencies, the new endoscope utilizes spatial frequency domain imaging. This new technique corrects the image contrast problem by projecting patterns of light at different frequencies on the cancer cells. This results in a high-contrast map of the tumor environment.
“We expect doctors in the operating room will greatly benefit from this device,” Sunar says.The next step is to zap the tumors.
Chemotherapy drugs will be delivered intravenously. But unlike conventional treatment, the drugs will be encapsulated in tiny liposomes called nanoballoons. This technology – under development by Jonathan Lovell, UB assistant professor of biomedical engineering – carries the drugs to the tumor while shielding them from healthy cells, thus reducing side effects. Upon reaching the cancer cells, doctors strike the nanoballons with the endoscopic light beam, causing them to pop open and release the drug directly at the tumor.
To effectively target the nanoballoons, doctors need to control the light beam. Sunar is developing a “digital mask” that adjusts the beam’s intensity as well as manipulates its shape down to micron (one millionth of a meter) precision using a computer.
“The mask is sort of like the Bat signal from Batman movies. It alters the shape of the light,” he says. “At the same time, we’ll be able to control the strength of the light. The combination will allow us to manipulate the beam to target cancer cells with unprecedented accuracy.”
The system could be especially useful for treating ovarian cancer that has spread to the abdomen, as well as cancer in the lungs, gastrointestinal tract, mouth and other internal organs, he said.
National Institutes of Health grant has supported the research and Sunar will spend much of 2015 developing the system and test it on animal models. Upon completion of the grant in 2016, he expects to begin a pilot study with Shashikant Lele, clinical chief of gynecologic oncology at Roswell Park Cancer Institute, and professor of gynecology and obstetrics at the UB School of Medicine and Biomedical Sciences.