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Scientists reveal how ‘O’ blood group protects against malaria

Many South africans, especially those fron Nigeria, have been known for malaria resistance and now for the first time Scandinavian scientists have decoded the reason why the protection in the form of ‘O’ blood type is inherent in them naturally.

The team from Karolinska Institutet in Sweden identified a new and important piece of the puzzle by describing the key part played by the RIFIN protein, using data from different kinds of experiment on cell cultures and animals.

(140407) -- MANILA, April 7, 2014 (Xinhua) -- People perform the "mosquito dance" to mark the World Health Day at the Philippine Department of Health (DOH) in Manila, the Philippines, April 7, 2014. The DOH unveiled its "mosquito dance" in an effort to renew focus on mosquito-control to prevent the spread of dengue, malaria and other vector-borne diseases and as a response to the World Health Organization's (WHO) call to control the spread of mosquito-borne diseases. (Xinhua/Rouelle Umali)  ****Authorized by ytfs****

(140407) — MANILA, April 7, 2014 (Xinhua) — People perform the “mosquito dance” to mark the World Health Day at the Philippine Department of Health (DOH) in Manila, the Philippines, April 7, 2014. The DOH unveiled its “mosquito dance” in an effort to renew focus on mosquito-control to prevent the spread of dengue, malaria and other vector-borne diseases and as a response to the World Health Organization’s (WHO) call to control the spread of mosquito-borne diseases. (Xinhua/Rouelle Umali)
****Authorized by ytfs****

The team showed how the Plasmodium falciparum parasite secretes RIFIN, and how the protein makes its way to the surface of the blood cell, where it acts like glue and the they also demonstrated how it bonds strongly with the surface of type A blood cells, but weakly to type O.

It suggests that the selective pressure imposed by malaria may contribute to the variable global distribution of ABO blood groups in the human population.

According to principal investigator Mats Wahlgren, professor at Karolinska Institutet’s department of microbiology, tumour and cell biology, the finding is “conceptually simple”.

However, since RIFIN is found in many different variants, it has taken the research team a lot of time to isolate exactly which variant is responsible for this mechanism.

“We can now explain the mechanism behind the protection that blood group O provides against severe malaria, which can, in turn, explain why the blood type is so common in the areas where malaria is common,” Wahlgren added.

In Nigeria, for instance, more than half of the population belongs to blood group O, which protects against malaria.

It has long been known that people with blood type O are protected against severe malaria, while those with other types, such as A, often fall into a coma and die.

Malaria infects 200 million people a year, 600,000 of whom, primarily children under five, fatally.

Malaria, which is most endemic in sub-Saharan Africa, is caused by different kinds of parasites from the plasmodium family, and effectively all cases of severe or fatal malaria come from the species known as Plasmodium falciparum.

The study was published in the journal Nature Medicine.

 

 

 

IANS

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