More than women with O blood group, women A, B and AB are rpone to type 2 diabetes, revealed an empirical study undertaken by researchers at the Centre for Research in Epidemiology and Population Health in France.
The study examined more than 80,000 women in France between 1990 and 2008 to conclude that different risks of developing type 2 diabetes are associated with different blood groups and the biggest difference of 35% increased risk for the chronic disease was found in those with group B, Rhesus factor positive (R+) blood compared with the universal donor group O, Rhesus factor negative (R-).
Lead author Guy Fagherazzi and his colleagues studied 82,104 women from the E3N cohort in France to study the link between ABO blood type (A, B, AB and O), Rhesus factor (positive or negative) and a combination of the two in causing the type 2 diabetes.
The results showed that, compared to women with group O blood, women with group A were 10% more likely to develop Type 2 diabetes and those with group B who have 21% risk. The AB group was 17% more likely to develop diabetes.
Compared with O- women, the highest increased risk of developing Type 2 diabetes was found in B+ (35 percent increased risk), followed by AB+ (26 percent), A- (22 percent), A+ (17 percent).
While the research was not able to find out the reasons behind the link between the blood group and diabetes, researchers suggest that it could be that the human ABO locus might influence endothelial or inflammation markers. The ABO blood groups are linked with various molecules known to be causative factors for Type 2 diabetes.
However, looking solely at R+ versus R- women, neither group was at increased risk of developing type 2 diabetes compared with the other and it requires further pathophysiological research to determine the link factors. Otherwise, the study for the first time shows a large prospective cohort that specific ABO blood groups are associated with an increased type 2 diabetes risk.
“Our findings support a strong relationship between blood group and diabetes risk, with participants with the O blood type having a lower risk of developing Type 2 diabetes,” said Guy Fagherazzi.
The study was published in the journal Diabetologia.