A drug used for eliminating intestinal parasites, if modified, could treat the root cause of type 2 diabetes and not just its symptoms as the current medicines are, discovered scientists. The finding may revolutionize the Diabetes 2 treatment permanently.
The Type 2 diabetes hits the when it fails to produce enough insulin and the major cause for it was insulin resistance due to excessive fat in the cells of the liver and muscles.
Scientist Victor Shengkan Jin, an associate professor of pharmacology at Rutgers Robert Wood Johnson Medical School, found that the fat disrupts the ability of the correct insulin absorption in the body to use it as an energy source for tissues.
The excessive glucose mostly remains in the blood and high concentrations lead to blindness, kidney damage, cardiovascular diseases and other related health issues, said Jin.
“Our goal in this study was to find a safe and practical way of diminishing fat content in the liver. We used mice to perform proof-of-principle experiments in our laboratory,” he said. “We succeeded in removing fat, and that in turn improved the animals’ ability to use insulin correctly and reduce blood sugar,” he said.
He modified niclosamide ethanolamine salt (NEN), which has burned the excess fat in liver cells in mitochondrial uncoupling that burns fuels including fats and sugars in modest quantities to keep the cells functional.
Though the outcome is still far from certain, Jin said the positive changes in the mice are encouraging and the drug he used is a modified form of a medication that was already approved by the US Food and Drug Administration.
The study has been published in the journal Nature Medicine.