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Individuals with A, B, AB Blood Groups at Higher Risk of Type 2 Diabetes

A recent study shows that women with blood groups A, B and AB are at higher risk of developing Type 2 diabetes when compared to individuals with blood type O.

For the study, the researchers collected data from more than 80,000 women in France followed between 1990 and 2008. “Our findings support a strong relationship between blood group and diabetes risk, with participants with the O blood type having a lower risk of developing Type 2 diabetes,” said Guy Fagherazzi from Centre for Research in Epidemiology and Population Health in France.

The results showed that, compared to women with group O blood, women with group A were 10 percent more likely to develop Type 2 diabetes and those with group B 21 percent more likely.

The AB group was 17 percent more likely to develop Type 2 diabetes.

The results showed that, compared with women with group O blood, women with group A were 10% more likely to develop T2D, and those with group B 21% more likely (both statistically significant). The AB group was 17% more likely to develop T2D, but this result was not statistically significant. When looking solely at R+ versus R- women, neither group was at increased risk of developing T2D compared with the other.

“The present study shows for the first time in a large prospective cohort that specific ABO blood groups are associated with an increased Type 2 diabetes risk,” Fagherazzi said. He added, “Our findings support a strong relationship between blood group and diabetes risk, with participants with the O blood type having a lower risk of developing type 2 diabetes. Therefore, the effects of blood groups should be investigated in future clinical and epidemiological studies on diabetes.

The authors say that the reasons behind the association are currently unknown, but could be related to a number of factors.

It has been suggested that the human ABO locus might influence endothelial or inflammation markers.

ABO grouping is also associated with various molecules known to be connected to Type 2 diabetes.

The study was published in the journal Diabetologia. (IANS)

 

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