Bangalore-based Indian Institute of Science (IISc) scientists have come out with new nanocapsules with ability to deliver drugs to cancer-hit human cells inside the body and prevent death of healthy cells due to cancer.
Nanocapsules help in cancer treatment as they can deliver drugs right inside a cancerous cell with physiological cues inside the body and deliver the drug to the target specified, thus ending one of the major obstacles in treating cancer.
Led by Prof Ashok M Raichur, Dipshikha Chakravortty and the team of scientists at IISc Bangalore, demonstrated the role of nancapsules and their use inside the body to treat cancer.
The study was conducted by Rajasegaran E., a research student, who was cleared for Ph.D. based on the findings in March this year. His thesis was titled,”Biodegradable Polyelectrolyte Multilayered Nanocapsules As Carriers for Targeted Gene and Anticancer Drug Delivery Applications : In Vitro and In vivo studies”.
The entire proces of drug delivery takes place in 3 steps:
Drug should be manufactured in the form of capsuled drug molecules and should not release prematurely inside the body or degrade, hence nano capsules help the delivery mode. The drug should reach target specified; and release the drug molecules using cues inside the body of the patient .
Based on these ideal characteristics, the scientists manufactured hollow nanocapsules from special materials called biopolymers that do not react with body tissues.
Hollow nanocapsules were fabricated from special materials called biopolymers, which are materials that do not react with body tissues.
These nanocapsules contain components that can respond to local cues integrated in the walls. To avoid premature release of the drug, the walls are cross-linked; this sort of architecture gives scope to load large amounts of drugs into the capsule.
The wall structure also makes it possible for a small amount of local cues, like enzymes, to trigger the release of a large number of drug molecules.
If proved right, the invention will help the Indian Institute of Science(IISc), which ranks 11th globally for high research output but faced considerable slide in the latest Quacquarelli Symonds (QS) World University Rankings.