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Cancer Diagnosis Through New Lens-Free Microscope at Cellular Level

A lens-free microscope that can be used to detect the presence of cancer or other cell-level abnormalities with the same accuracy as larger and more expensive optical microscopes, has been developed by researchers.

According to researchers, the invention may lead to less expensive and more portable technology for performing common examinations of tissue, blood and other biomedical specimens.

“This is the first time that tissue samples have been imaged in 3D using a lens-free on-chip microscope,” noted Aydogan Ozcan, professor of electrical engineering and bioengineering at University of California, Los Angeles.

The method may prove useful in remote areas and in cases where large numbers of samples need to be examined quickly.

The latest invention is the first lens-free microscope, which can be used for high-throughput 3-D tissue imaging, key to study the disease.

The device works by using a laser or light-emitting-diode to illuminate a tissue or blood sample that has been placed on a slide and inserted into the device. A sensor array on a microchip, the same type of chip that is used in digital cameras, including cell phone cameras that capture and record the pattern of shadows created by the sample.

The team tested the device using Pap smears which indicated cervical cancer, tissue specimens containing cancerous breast cells and blood samples containing sickle cell anaemia. The device processes these patterns as a series of holograms, forming 3-D images of the specimen and giving medical personnel a virtual depth-of-field view.

Amid, another benefit of the lens-free device is that it produces images which are many hundred times larger in area, or field of view, than those captured by conventional bright-field optical microscopes.

“Accompanied by advances in its graphical user interface, this platform could scale up for use in clinical, biomedical, scientific, educational and citizen-science applications, among others,” Ozcan said.

The study appeared in Science Translational Medicine. (IANS)


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