People who take more antibiotics tend to run the risk of getting the Type 2 diabetes compared to those who did not have the condition, said a new study.
The findings have been published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.
Diabetes is characterized by high blood sugar levels, when the individual fails to produce enough of the hormone insulin or insulin does not work properly to clear sugar from the bloodstream.
More than 29 million Americans have diabetes, according to the Society’s Endocrine Facts and Figures report. Type 2 diabetes, the most common form of the condition, accounts for 90 to 95 percent of all cases.
“In our research, we found people who have Type 2 diabetes used significantly more antibiotics up to 15 years prior to diagnosis compared to healthy controls,” said co-author Kristian Hallundbæk Mikkelsen, of Gentofte Hospital in Hellerup, Denmark.
“Although we cannot infer causality from this study, the findings raise the possibility that antibiotics could raise the risk of Type 2 diabetes. Another equally compelling explanation may be that people develop Type 2 diabetes over the course of years and face a greater risk of infection during that time.”
The researchers tracked antibiotic prescriptions for 170,504 people who had Type 2 diabetes and for 1.3 million people who did not have diabetes and identified the subjects using records from three national health registries in Denmark.
People who had Type 2 diabetes filled 0.8 prescriptions a year, on average. The rate was only 0.5 prescriptions a year among the study’s participants. Those who filled more prescriptions were more likely to be diagnosed with Type 2 diabetes. Many types of antibiotics were associated with a higher risk of diabetes, but there was a stronger link with the use of narrow-spectrum antibiotics such as penicillin V, said the study finding.
Past studies have shown that antibiotic treatments can alter the bacteria in an individual’s gut and certain gut bacteria may contribute to the impaired ability to metabolize sugar seen in people with diabetes. This may explain why higher rates of antibiotic use reflect in developing Type 2 diabetes, explained Mikkelsen.
“Further investigation into long-term effect of antibiotic use on sugar metabolism and gut bacteria composition could reveal valuable answers about how to address this public health crisis. Patterns in antibiotic use may offer an opportunity to prevent the development of the disease or to diagnose it early,” he added.